Abstract

Hoang Van Minh1*, Nguyen Thi Tuyet My1 and Mark Jit2,3  

Background: Cervical cancer is currently the leading cause of cancer mortality among women in South Vietnam and the second leading cause of cancer mortality in North Vietnam. Human papillomavirus (HPV) vaccination has the potential to substantially decrease this burden. The World Health Organization (WHO) recommends that a costeffectiveness analysis of HPV vaccination is conducted before nationwide introduction.

Methods: The Papillomavirus Rapid Interface for Modeling and Economics (PRIME) model was used to evaluate the cost-effectiveness of HPV vaccine introduction. A costing study based on expert panel discussions, interviews and hospital case note reviews was conducted to explore the cost of cervical cancer care.

Results: The cost of cervical cancer treatment ranged from US$368 – 11400 depending on the type of hospital and treatment involved. Under Gavi-negotiated prices of US$4.55, HPV vaccination is likely to be very cost-effective with an incremental cost per disability-adjusted life year (DALY) averted in the range US$780 - 1120. However, under list prices for Cervarix and Gardasil in Vietnam, the incremental cost per DALY averted for HPV vaccination can exceed US$8000.

Conclusion: HPV vaccine introduction appears to be economically attractive only if Vietnam is able to procure the vaccine at Gavi prices. This highlights the importance of initiating a nationwide vaccination programme while such prices are still available.

Keywords: Cost-effectiveness analysis, Cervical cancer, Vietnam, PRIME, Human papillomavirus  

* Correspondence: hvm@huph.edu.vn
1Hanoi University of Public Health, Building A, 1A Duc Thang Road, Duc Thang Ward, North Tu Liem District, Hanoi, Vietnam
Full list of author information is available at the end of the article